This webpage provides step-by-step instructions for the creation of structured pathways that can be published in the PANTHER Pathway database. The PANTHER Pathway ontology comprises a data structure for pathways, their components and reactions, and the relationships among them. An overview of the infrastructure and curation process is described in Mi et al. 2007.

PANTHER Pathway is a community effort. We give full credit to all our contributors on PANTHER website.

Please contact pathcuration@pantherdb.org for any questions.

Before you start

1. Go to PANTHER Pathway Release Calendar to see which pathways have been released or are currently being worked on.
2. Send an email to pathcuration@pantherdb.org to propose the pathway that you are going to curate. Please include your qualifications in the email. We will add the pathway to our Release Calendar to ensure no redundant work is done.

Draw pathway diagram using CellDesigner

1. Download CellDesigner
2. Read our CellDesigner Tutorial. Even if you are familiar with CellDesigner, please look over the tutorial, as we define and provide examples of some drawing conventions that will maximize the information available in the pathways.
3. Draw pathway diagram using CellDesigner. Send questions to pathcuration@pantherdb.org for any assistance.
4. Email your diagram (in SBML format) to pathcuration@pantherdb.org.

After your curated pathway is submitted, it will be integrated into our database for the next phase of curation. This process will take between 2-4 weeks (we plan to make this process faster in the future). We will inform you via email once it is ready.

Associate sequences to pathways

Associate sequences with macromolecule classes in the pathway, and enter additional information such as descriptions of the pathway and molecules, and literature references.

1. Read our pathway sequence association tutorial (pdf, ppt).
2. Register online to create a curation account.
3. You need to complete the mandatory online training. Your account will be approved upon completion of the training.
4. Start the sequence association process.